Triazenation Unable Selective Reaction of Secondary Amines (TrUSS) for Tagging Monomethyl Lysine PTMs

Abstract Lysine monomethylation Kme is an impactful postā€translational modification PTM responsible for regulating biological processes and implicated in diseases thus there is great interest in identifying these methylation marks globally. However, the progress in this area has been challenging because the addition of a small methyl group on lysine leads to negligible change in the……

Secondary amine selective Petasis (SASP) Bioconjugation

Abstract Selective modification of proteins enables synthesis of antibody-drug conjugates, cellular drug delivery and construction of new materials. Many groups have developed methods for selective N-terminal modification without affecting the side chain of lysine by judicious pH control. This is due to lower basicity of the N-terminus relative to lysine side chains. But none of……