Publications

Villalobos Galindo, A.; Raj, M. Solvent-Dependent Chemoselectivity Switch to Arg-Lys Imidazole Cross-Links. Org. Lett. 2024, 26, 8356. (pdf)

Sahu, S.*; Emenike, B.*; Buesch, C. M.; Bagchi, P.; Gordon, D. E.; Raj, M. Copper(I)-nitrene platform for chemoproteomic profiling of methionine. Nat. Commun. 2024, 15, 4243. (pdf)

Bruce, A.*; Adebomi, V.*; Czabala, P.; Palmer, J.; McFadden, W. M.; Lorson, Z. C.; Slack, R. L.; Bhardway, G.; Sarafianos, S. G.; Raj, M. A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries. Angew. Chem., Int. Ed. 2024, 63, e202320045. (pdf)

Emenike, B.; Czabala, P.; Farhi, J.; Swaminathan, J.; Anslyn, E. V.; Spangle, J.; Raj, M. Tertiary Amine Coupling by Oxidation for Selective Labelling of Dimethyl Lysine Post-Translational Modifications. J. Am. Chem. Soc. 2024, 146, 10621-10631. (pdf)

Emenike, B.*; Shahin, S.*; Raj, M. Bioinspired Synthesis of Allysine for Late-Stage Functionalization of Peptides. Angew. Chem., Int. Ed. 2024 e202403215. (pdf)

Wills, R.*; Shirke, R.*; Hrncir, H.; Talbott, J. M.; Sad, K.; Spangle, J. M.; Gracz, A. D.; Raj, M. Tunable fluorescent probes for detecting aldehydes in living systems. Chem. Sci. 2024, 15, 4673-4769. (pdf) Selected for Cover Image

Paikin, Z. E. P.; Talbott, J. M.; Raj, M. Regioselective Aldehyde Decarbonylation through Palladium-Catalyzed Nitrile Boronic Acid Cross-Coupling. Synlett 2024, eFirst. (pdf)

2023

Prosser, L. P.*; Talbott, J. M.*; Garrity, R. P.; Raj, M. C-Terminal Arginine-Selective Cleavage of Peptides as a method for Mimicking Carboxypeptidase B. Org. Lett. 2023, 25, 6206-6210. (pdf)

Most viewed Org. Lett. article of August 2023

Emenike, B.; Donovan, J.; Raj, M. Multicomponent Oxidative Nitrile Thiazolidination Reaction for Selective Modification of N-terminal Dimethylation Posttranslational Modification. J. Am. Chem. Soc. 2023, 154, 16417-16428. (pdf)

Wills, R.; Farhi, J.; Czabala, P.; Shahin, S.; Spangle, J. M.; Raj, M. Chemical sensors for imaging total cellular aliphatic aldehydes in live cells. Chem. Sci. 2023, 14, 8305-8314. (pdf)

Shao, H.; Adebomi, V.; Bruce, A.; Raj, M.; Houk, K. N. Intramolecular Hydrogen Bonding Enables a Zwitterionic Mechanism for Macrocyclic Peptide Formation: Computational Mechanistic Studies of CyClick Chemistry. Angew. Chem., Int. Ed. 2023, e202307210. (pdf)

Wang, Y.; Czabala, P.; Raj, M. Bioinspired one-pot furan-thiol-amine multicomponent reaction for making heterocycles and its applications. Nat. Commun. 2023, 14, 4086-4101. (pdf)

Emenike, B.; Nwajiobi, O.; Raj, M. Covalent chemical tools for profiling post-translational modifications. Front. Chem. 2022, 10, 868773,  DOI: 10.3389/fchem.2022.868773 (pdf)

Wills, R.; Adebomi, V.; Spancake C.; Raj, M. Synthesis of L-Cyclic Tetrapeptides by Backbone Amide Activation CyClick Strategy. Tetrahedron 2022, 126, 133071. (pdf)

Nwajiobi, O.; Verma, A.; Raj, M. Rapid Arene Triazene Chemistry for Macrocyclization. J. Am. Chem. Soc. 2022, 144, 4633-4641. (pdf)

Tang, K.-C.; Maddox, S.; Backus, K. M.; Raj, M. Tunable Heteroaromatic Azoline thioethers (HAT) for Cysteine Selective Modification and Proteome profiling. Chem. Sci. 2022, 13, 763-774. (pdf)

Tang, K.-C.; Cao, J.; Boatner, L. M.; Li, L.; Farhi, J.; Houk, K. N.; Spangle, J.; Backus, K. M.; Raj, M. Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew. Chem., Int. Ed. 2022, 61, e202112107. (pdf)

Adebomi, V.; Sriram, M.; Streety, X.; Raj, M. Metal-Free Selective Modification of Secondary Amides: Application in Late-Stage Diversification of Peptides. Org. Lett. 2021, 23, 6189–6193. (pdf)

Nwajiobi, O.; Sriram, M.; Streety, X.; Raj, M. Selective Triazenation Reaction (STaR) of Secondary Amines for Tagging Monomethyl Lysine Post-Translational Modifications. Angew. Chem., Int. Ed. 2021, 60, 7344-7352. (pdf)

Tang, K.-C.; Raj, M. One step azolation strategy for site- and chemo-selective labeling of proteins with mass sensitive probes. Angew. Chem., Int. Ed. 2021, 60, 1797-1805. (pdf)

Wills, R.; Adebomi, V.; Raj, M. Site selective peptide macrocyclization. ChemBioChem. 2020, 22, 52-62. (Invited Review article) (pdf)

Wills, R.; Adebomi, V.; Raj, M. Peptide cyclization at high concentration. Synlett 2020, 31, 1537-1542. (Invited Review article) (pdf)

Sriram, M.; Adebomi, V.; Raj, M. Bioinspired nitroalkylation for selective protein modification and peptide stapling. Angew. Chem., Int. Ed. 2020, 59, 2793-2801. (pdf)

Sim, Y. E.; Nwajiobi, O.; Sriram, M.; Cohen, R. D.; Raj, M. Secondary amine selective peptide (SASP) bioconjugation. Chem. Sci. 2020, 11, 53-61. (pdf)

Adebomi, V.; Cohen, R. D.; Wills, R.; Chavers, H. A. H.; Martin, G. E.; Raj, M. CyClick chemistry for synthesis of cyclic peptides. Angew. Chem., Int. Ed. 2019, 58, 19073-19080. (pdf)

Sriram, M.; Tang, K.-C.; Raj, M. Amide bond activation of biological molecules. Molecules 2018, 23, 2615. (Invited Review article) (pdf)

Elashal, H. E.; Cohen, R. D.; Elashal, H. E.; Zong, C.; Link, A. J.; Raj, M. Cyclic and lasso peptides: sequence determination, topology analysis, and rotaxane formation. Angew. Chem., Int. Ed. 2018, 57, 6150-6154. (pdf)

Elashal, H. E.; Cohen, R. D.; Elashal, H. E.; Raj, M. Oxazolidinone-mediated sequence determination of one-bead one-compound cyclic peptide libraries. Org. Lett. 2018, 20, 2374-2377. (pdf)

Zong, C.; Ling, W.; Lee, C.; Elashal, H. E.; Raj, M.; Link, A. J. Albusnodin: an acetylated lasso peptide from Streptomyces albus. Chem. Commun. 2018, 54, 1339-1342. (pdf)

Elashal, H. E.; Sim, Y. E.; Raj, M. Serine promoted synthesis of peptide thioester-precursor on solid support for native chemical ligation. Chem. Sci. 2017, 8, 117-123. (pdf)

Elashal, H. E.; Cohen, R. D.; Raj, M. Fmoc solid-phase synthesis of C-terminal modified peptides by formation of a backbone cyclic urethane moiety. Chem. Commun. 2016, 52, 9699-9702. (pdf)

Elashal, H. E.; Raj, M. Site-selective chemical cleavage of peptide bonds. Chem. Commun. 2016, 52, 6304-6307. (pdf)

Nalbone, J. M.; Lahankar, N.; Buissereth, L.; Raj, M. Glutamic acid selective chemical cleavage of peptide bonds. Org. Lett. 2016, 18, 1186–1189. (pdf)